A Mechanism of Resistance to Fluoropyrimidines.
نویسندگان
چکیده
uridylic acid. The increase in the metabolic activity of a mutant is a reflection of the extent to which the corresponding analog is converted to the active intermediate. No differences in the rate of uptake of 5-fluorouracil were observed between the sensi tive or resistant strains. Resistance to a fluoropyrimidine is accompanied by com plete cross-resistance to the less potent fluoropyrimidines and by partial resistance to ward the more potent fluoro-derivatives.
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عنوان ژورنال:
- Cancer research
دوره 24 شماره
صفحات -
تاریخ انتشار 1964